Mouse liver cells are frequently employed in research. The liver comprises many cells. While liver hepatocytes constitute about 70-80% of its mass, mast cells contribute to the liver's immune system. Mus liver hepatocytes are responsible for metabolism, detoxification, protein synthesis, and bile production. Mouse Liver mast cells, though fewer in number, release histamine, cytokines, and other mediators during immune responses. Both work together during injury or infection. Liver hepatocytes have a remarkable ability to regenerate or repair injury.

Culturing primary cells has offered insights into cellular pathways and disease pathogenesis. The similarities that are shared with tissue have promoted the use of these cells in research. The data from primary cell culture research is reproducible in the in vivo models. Recent studies have been divulging the difference between genome, transcriptome, and signaling pathways of cells from different tissues. It has further promoted the isolation and culture of primary cells from different tissues and species, adding precision to research.

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Culturing primary cells has offered insights into cellular pathways and disease pathogenesis. The similarities that are shared with tissue have promoted the use of these cells in research. The data from primary cell culture research is reproducible in the in vivo models. Recent studies have been divulging the difference between genome, transcriptome, and signaling pathways of cells from different tissues. It has further promoted the isolation and culture of primary cells from different tissues and species, adding precision to research.

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Neural progenitor cells can create specific neural lineages and thus contribute to the tissue functions. Their role in neurogenesis has implicated them in nervous system injury and disease. The in vitro culture of these cells has found applications in exploring neural development pathways, understanding neurological disorders, and evaluating drug efficacy. Their use in regenerative medicine has captivated the scientific community. It is investigating the potential of neural progenitor cells in neurodegenerative conditions such as Alzheimer’s disease, Parkinson’s disease, etc.

Development of kidney epithelial cells

Renal research has focused on the development of kidney epithelial cells. The renal epithelium is quite heterogeneous, showing variability in different regions of the nephron. Some studies have reported that during tissue repair, differentiated epithelial cells dedifferentiate into mesenchymal cells.

It has spurred the analysis of these cells and their developmental pathways. Kidney epithelium originates from intermediate mesoderm, and the organ undergoes three stages- pronephros, mesonephros, and metanephros.